产品特性
Anti Dibromotyrosine(DiBrY) monoclonal antibody
纯化：Protein A purified.
Specificity: Specific for di-halogenated tyrosine.
Suitable for immunohistocheistry, western blotting and ELISA.
| 规格 | 价格 |
|---|---|
| 20 µg | ￥咨询 |
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详细介绍
产品名称：Dibromo-Tyrosine(DiBrY)抗体
别名：Anti Dibromotyrosine monoclonal antibody；Anti Dibromotyrosine antibody；Anti Dibromo-tyrosine Monoclonal Antibody；Anti Dibromo-tyrosine Antibody；Anti Dibromo tyrosine Antibody；Anti DiBrY Monoclonal Antibody；Anti DiBrY Antibody；Dibromotyrosine抗体；Dibromo-tyrosine抗体；DiBrY抗体；抗二溴酪氨酸单克隆抗体；抗二溴酪氨酸抗体
应用：Immunohistochemistry, western blotting and ELISA.
克隆：3A5
储存条件：Less than -20°C
蛋白质氧化新型生物标志物
Neutrophils and eosinophils play an important role in the defence system against microbial infection. Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are known to catalyze formation of hypochlorous acid (HOCl) and hypobromous acid (HOBr). These reactive intermediates may react with proteins, lipids and nucleotides, and it has been reported to form tyrosine halogenation such as dibromotyrosine (DiBrY). DiBrY is a Br-modified tyrosine at 3- and 5- position, which is one of the major oxidative products derived from neutrophil myeloperoxidase.
特异性针对3位和5位二卤代酪氨酸
Monoclonal antibody clone 3A5 have been established by Dr. Toshihiko Osawa (Nagoya Univ.) and Dr. Yoji Kato (Univ. Hyogo). This antibody is specific for 3,5-Dibrominated tyrosine and other di-halogenated tyrosine at 3- and 5- position. Suitable for immunohistochemical analysys of oxidative stress.
酪氨酸的氧化修饰
Tyrosine is one of the main targets of protein oxidation, and it have been reported form nitrotyrosine, dityrosine and halogenated tyrosines depending on the type of free radicals. For example, hypochlorous acid (HOCl) and hypobromous acid (HOBr) are derived from neutrophil myeloperoxidase (MPO) and eosinophil peroxidase (EPO), and known to form dihalogenated tyrosines such as DiBrY, DiClY and DiIY. It is expected that DiBrY may be a novel biomarker for tissue damage which is related to inflammatory and allergic disorders.
抗原：3,5-dibromotyrosine conjugated KLH(keyhole limpet hemocyanin).
形式：Lyophilized power. Reconstitute by 200 µL of distilled water. 100 µg/mL of IgG.
亚类：Mouse IgG1(kappa).
纯化：Protein A purified.
特异性：This antibody can react with dibromotyrosine (DiBrY), N-acetylated dichloro tyrosine (NAcDiClY), diiodo tyrosine (DiIY), N-bromosuccinimide-treated BSA, HOCl-treated BSA and dibromo-tyrosone conjugated BSA (halogene-modified tyrosine at both 3- and 5-position).
Cross reactivity to following analogues have been tested：
dityrosine-conjugated BSA, peroxynitrite-treated BSA, tyrosine (Y), chrolotyrosine(ClY), 3-3’-dityrosine (DiY), 3-aminotyrosine (NH2Y), 3-nitrotyrosine (NO2Y), phenylalanine (Phe), o-phosphotyrosine, 3,4-dihydroxyphenylacetic acid (DOPA) and 2-hydroxy-4-phenylacetic acid. Weakly react with Bromotyrosine (BrY).
[注意事项]：我们的抗二溴酪氨酸（Dibromotyrosine）单克隆抗体仅用于研究用途。不可用于诊断、医疗或其他用途。
[NOTICE]: Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or other use.
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Neutrophils and eosinophils play an important role in the defence system against microbial infection. Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are known to catalyze formation of hypochlorous acid (HOCl) and hypobromous acid (HOBr). These reactive intermediates may react with proteins, lipids and nucleotides, and it has been reported to form tyrosine halogenation such as dibromotyrosine (DiBrY). DiBrY is a Br-modified tyrosine at 3- and 5- position, which is one of the major oxidative products derived from neutrophil myeloperoxidase.
特异性针对3位和5位二卤代酪氨酸
Monoclonal antibody clone 3A5 have been established by Dr. Toshihiko Osawa (Nagoya Univ.) and Dr. Yoji Kato (Univ. Hyogo). This antibody is specific for 3,5-Dibrominated tyrosine and other di-halogenated tyrosine at 3- and 5- position. Suitable for immunohistochemical analysys of oxidative stress.
酪氨酸的氧化修饰
Tyrosine is one of the main targets of protein oxidation, and it have been reported form nitrotyrosine, dityrosine and halogenated tyrosines depending on the type of free radicals. For example, hypochlorous acid (HOCl) and hypobromous acid (HOBr) are derived from neutrophil myeloperoxidase (MPO) and eosinophil peroxidase (EPO), and known to form dihalogenated tyrosines such as DiBrY, DiClY and DiIY. It is expected that DiBrY may be a novel biomarker for tissue damage which is related to inflammatory and allergic disorders.
抗原：3,5-dibromotyrosine conjugated KLH(keyhole limpet hemocyanin).
形式：Lyophilized power. Reconstitute by 200 µL of distilled water. 100 µg/mL of IgG.
亚类：Mouse IgG1(kappa).
纯化：Protein A purified.
特异性：This antibody can react with dibromotyrosine (DiBrY), N-acetylated dichloro tyrosine (NAcDiClY), diiodo tyrosine (DiIY), N-bromosuccinimide-treated BSA, HOCl-treated BSA and dibromo-tyrosone conjugated BSA (halogene-modified tyrosine at both 3- and 5-position).
Cross reactivity to following analogues have been tested：
dityrosine-conjugated BSA, peroxynitrite-treated BSA, tyrosine (Y), chrolotyrosine(ClY), 3-3’-dityrosine (DiY), 3-aminotyrosine (NH2Y), 3-nitrotyrosine (NO2Y), phenylalanine (Phe), o-phosphotyrosine, 3,4-dihydroxyphenylacetic acid (DOPA) and 2-hydroxy-4-phenylacetic acid. Weakly react with Bromotyrosine (BrY).
[注意事项]：我们的抗二溴酪氨酸（Dibromotyrosine）单克隆抗体仅用于研究用途。不可用于诊断、医疗或其他用途。
[NOTICE]: Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or other use.
