Murine Anti-Factor IX抗体(GMA-001)
货号：GMA-001
品牌：Greenmoab
产品特性
Specificity：Gla domain (residues 1-40) of FIX/FIXa
Immunogen：Human Factor IX
Application：ELISA,Immunoblotting and Inhibition
| 规格 | 价格 |
|---|---|
| 0.1 mg | ￥咨询 |
| 0.5 mg | ￥咨询 |
产品咨询：info@biopcr.com
产品订购：sales@biopcr.com
技术支持：tech@biopcr.com
服务热线：400-860-6200
详细介绍
产品名称：Murine Anti-Factor IX抗体(GMA-001)
别名：Murine Anti-Factor IX Antibody；Murine Anti-Factor IX Monoclonal Antibody；Murine Anti-Factor IX单克隆抗体；Factor IX抗体；Murine Anti-Factor IX抗体；小鼠抗凝血因子IX抗体；Mouse Anti-Factor IX Antibody；F8抗体
克隆号（Clone）：GMA-001
背景介绍（Background）：
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Absent or defective FIX is the cause of the X-linked recessive bleeding disorder hemophilia B. GMA-001 (BC2) binds to the N-terminal Gla domain of FIX and the light chain of FIXa, as detected by Western blot and ELISA. In addition, GMA-001 prolongs clotting time in APTT-based plasma clotting assays and prevents arterial thrombosis in vivo in a rat model1.
种属反应性（Species Reactivity）: Human, Rat
来源（Source）： Murine
特异性（Specificity）： Gla domain (residues 1-40) of FIX/FIXa
免疫原（Immunogen）： Human Factor IX
亚型（Isotype）： IgG2a
应用（Application）：
ELISA： Binds immobilized Human and Rat FIX, Human FIXa only in the presence of calcium.
Immunoblotting： Western blot detects Human FIX and light chain of Human FIXa under reduced conditions in presence of calcium.
Inhibition： Prolongs plasma clot time in APTT clotting assay.
储存（Storage）：Aliquot and store at -20℃ for prolonged periods. Avoid freeze-thaw cycles. Alternatively, add 0.02% (w/v) sodium azide and store at 4℃.
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背景介绍（Background）：
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Absent or defective FIX is the cause of the X-linked recessive bleeding disorder hemophilia B. GMA-001 (BC2) binds to the N-terminal Gla domain of FIX and the light chain of FIXa, as detected by Western blot and ELISA. In addition, GMA-001 prolongs clotting time in APTT-based plasma clotting assays and prevents arterial thrombosis in vivo in a rat model1.
种属反应性（Species Reactivity）: Human, Rat
来源（Source）： Murine
特异性（Specificity）： Gla domain (residues 1-40) of FIX/FIXa
免疫原（Immunogen）： Human Factor IX
亚型（Isotype）： IgG2a
应用（Application）：
ELISA： Binds immobilized Human and Rat FIX, Human FIXa only in the presence of calcium.
Immunoblotting： Western blot detects Human FIX and light chain of Human FIXa under reduced conditions in presence of calcium.
Inhibition： Prolongs plasma clot time in APTT clotting assay.
储存（Storage）：Aliquot and store at -20℃ for prolonged periods. Avoid freeze-thaw cycles. Alternatively, add 0.02% (w/v) sodium azide and store at 4℃.
